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KMID : 0371619980140020321
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Journal of Wonkwang Medical Science
1998 Volume.14 No. 2 p.321 ~ p.325
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The Usefulness of Continuous I.V.Infusion of Low-Dose Droperidol As a Substitution for Granisetron for the Treatment of Gastrointestinal Symptoms from Palliative Radiation Therapy
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Moon Sun-Rock
Park Soo-Kyoung
Cheong Young-Pyo
Kim Tai-Yo
Choi Yu-Sun
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Abstract
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Background: Radiation therapy in palliative cancer management leads mainly to nausea, vomiting, dyspepsia and anorexia. Several agents have been used to treat above symptoms and sings. We assessed the usefulness of continuous intravenous infusion of low-dose droperidol, compared to granisetron for the control of gastrointestinal symptoms due to radiation therapy.
Method: We devided 30 patients who developed gastrointestinal symptoms after undergoing palliative radiation therapy due to metastatic bone pain in two groups. In group G(n=15), the patients were injected granisetron(3㎎) and then injected it, 3㎎ per day. In group D(n=15), the patients were injected low-dose droperidol(0.25㎎) and then infused continuously at low-dose(1㎎/day) by the disposable continuous infusion pump.
Result: There were no significant differences in the patient’s satisfaction, improvement of appetite and incidences of side effects between two groups.
Conclusion: The continuous intravenous infusion of low-dose droperidol can substitute for serotonin-receptor antagonist for the treatment of gastrointestinal symptoms during radiation therapy for cancer patients.
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KEYWORD
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Antimetics, droperiodol, ondansetron, grainsetron, complication, nausea
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